New Lupus Treatment Restores Immune Balance Is Really Effective

A cancer treatment from the 1990s may not be commonly used now, but a new study from Monash University shows that it could be very effective: not for cancer, but for lupus.Lupus, or systemic lupus erythematosus, is an autoimmune disease characterized by not balance of activity between the effector and regulator helper T cells of the immune system. Researchers guessed that this chronic disease, which can cause damage to virtually any organ in the body, affects more than 1.5 million Americans, most often women between the ages of 15 and 44.Current treatments for lupus come from immunosuppressive drugs, but they are often minimally effective. The present study suggests a new way to restore balance to the immune system in order to relieve the symptoms for patients with the lupus treatment is very effective.

The magic ingredient in this New Lupus Treatment? Interleukin (IL)-2. In their study, researchers gave IL-2 to lupus patients who weren’t being helped with the remaining lupus treatments, in much lower doses than operated to patients when the New Lupus Treatment was used to treat cancer.“It calms the hyperactive immune system through multiple mechanisms,” said Professor Eric Morand, founder of the Asia Pacific Lupus Collaboration. “This new therapy may be effective for many patients.”

IL-2 is a cytokine, a signaling molecule produced by immune cells for immune cells. Specifically, IL-2 modulates homeostasis of CD4+ T cells by regulating the abundance of regulatory T cells, follicular helper T cells, and IL-17-producing helper T cells. Follicular helper T cells are the “specialized providers of B cell help,” meaning they control the germinal center that produce antibody-creating plasma cells and memory B cells. IL-17-producing helper T cells play a vital role in the pathogenesis of autoimmune diseases, like lupus. Specifically, these cells facilitate the provoking process through stimulation of cytokines, chemokines, neutrophils, and macrophages.Patients with lupus show less production of IL-2 by T cells, suggesting that an IL-2 deficiency is at the root of their immune dysfunction.With the initial success of these IL-2 studies, clinical trials will soon be underway. Scientists are hopeful for the quick approval of this New Lupus Treatment, since preclinical trials have shown the IL-2 treatment to be effective and safe for treating lupus, and higher doses of the drug have been approved in the past.



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