Preliminary new research raises the prospect that a recently discovered antibody — an important component of the immune system — could be enlisted to boost the body’s response to HIV, the virus that causes AIDS.
A single injection of the antibody, currently dubbed VRC01, dramatically reduced the level of HIV in the blood of people who hadn’t yet been given antiretroviral drug treatment (ART). This is the current standard treatment for managing HIV infections, according to the study’s authors from the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases in Bethesda, Md.
Still, “this offers a potential alternative to antiretroviral therapy,” said Julian Ma, director of the Institute for Infection and Immunity at St. George’s Hospital Medical School in London. “We desperately need them given our dependence on a relatively small number of antiretroviral therapy drugs.”Eventually, this new approach could be combined with other treatments aimed at lowering levels of HIV in the body and preventing dangerous strains from emerging, Ma said. He wasn’t part of the research but was familiar with the study findings.
But many questions still remain. The study was small, and at this stage, little is known about the side effects, benefits and potential cost of the treatment.
Levels of the virus in the blood dropped or even vanished in six out of the eight HIV patients who hadn’t been taking ART. That doesn’t mean they were cured of HIV. The virus still remains in the body, just at undetectable levels. Those who didn’t respond to the treatment had strains of HIV that were resistant to the treatment, the study authors said.
The treatment’s costs are unknown, although Ma said these kinds of drugs are generally expensive, which potentially limits their use in poor countries.
Dr. James Crowe, director of the Vanderbilt Vaccine Center in Nashville, Tenn., said the study is impressive and promising. But he cautioned that the effects of single doses of the antibody treatment are “relatively minor and temporary,” and some patients quickly developed immunity to it. As a result, the antibody on its own isn’t likely to work as a long-term treatment, he said.
Ma praised the study but also cautioned about the challenge of HIV strains that are immune to the treatment.