Monday, January 18, 2021

Early Stroke Treatment For Patients Could Help Prevent Disability And Improve Chances Of Recovery

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Following the onset of a stroke treatment, restoring blood flow to the brain as quickly as possible is critical for preventing disability and improving the chances of recovery. This crucial window for treatment is a narrow one – about 4 ½ hours – and the earlier the treatment, the better the outcome.More than 7 million stroke survivors in the U.S. are left with persistent disability after a stroke, such as weakness or speech and language problems, often because treatment was given too late, or not at all. “Time lost is brain lost,” as one saying goes. Each minute of delay results in an estimated loss of 1.9 million neurons, which, over the course of an hour without treatment, can be roughly compared to 3.6 years of normal brain aging.

Stroke treatments must be administered in the emergency department, often in the form of a “clot-busting” drug called tPA, and can reduce the risk of disability by more than 30 percent. Yet because of a variety of barriers to timely evaluation and treatment, fewer than 5 percent of those who experience a stroke ever receive these therapies.Under a five-year, $2.5 million grant from the National Institute on Minority Health and Health Disparities, a team of University of Michigan researchers and community partners is embarking on a novel project to increase acute stroke treatment rates in the community of Flint, Michigan.

Led by Lesli Skolarus, M.D., M.S., an associate professor of neurology at the U-M Medical School and a board-certified vascular neurologist, the team is testing a hospital- and community-based intervention called the “Stroke Ready” program that will attempt to address delays that can occur before and after arrival to the hospital, ultimately reducing the likelihood of stroke treatment and lessening its effectiveness.

“Acute stroke treatments dramatically reduce post-stroke disability, but they are also extremely underutilized,” Skolarus explains. “We hope this program will boost stroke awareness in Flint and help get treatment to more stroke patients, so that the burden of stroke can be reduced in this community.”The project is co-led by community partners that include Hurley Medical Center, Bridges into the Future, an African-American faith-based community group in Flint, and Community Based Organization Partners, also headquartered in Flint, all of which Skolarus has collaborated with for many years. The Healthy Flint Research Coordinating Center, a collaboration between the Flint Community, UM-Flint, UM-Ann Arbor, and Michigan State University, is another partner in the project.

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