How CBD’s Is Beneficial For Bipolar Disorder Treatment
CBD’s Is very effective for bipolar disorder treatment and manic episodes.It has been shown that cannabidiol has anti-psychotic properties, particularly anxiolytic benefits in humans. CBD possesses hypnotic, anti-convulsive, neuroprotective, and anti-stress benefits. Based on this evidence, research studies have begun to investigate the anxiolytic and antipsychotic benefits of CBD, which may be useful in effective in bipolar disorder treatment.
The Neurochemistry of Bipolar Disorder and Cannabinoids
A dysfunctional endocannabinoid system (EC) has been implicated in mood disorders such as bipolar disorder, and modulation of the EC system by exogenous cannabinoids such as cannabidiol, tetrahydrocannabinol and anandamide can potentially treat bipolar disorder symptoms by exerting antipsychotic, anticonvulsant, and anxiolytic effects. Research studies have demonstrated the antipsychotic mechanism action of cannabidiol. Administration of cannabidiol may indirectly influence endogenous anandamide signaling by inhibiting intracellular metabolism by fatty acid amide hydrolase (FAAH). Elevated levels of anandamide can attenuate mood disturbances and treat bipolar disorder symptoms.
CBD can inhibit glutamate toxicity and offers anti-convulsant and mood-stabilizing benefits, which are similar to the benefits of conventional therapeutic drugs such as valproate and lithium that are indicated for bipolar disorder. In open-label human clinical trials, CBD has significantly reduced psychotic symptoms and normalized motor functions in psychiatric patients. These benefits can be useful to treat manic episodes in bipolar disorder patients.
The Neuroprotective, Anti-psychotic, and Anxiolytic Benefits of CBD
CBD can exert anti-oxidative (scavenging free radicals) and neuroprotective benefits in humans. In this study, CBD was found to be an inhibitor of oxidative damage (free radicals) and increased BDNF (brain-derived neurotrophic factor) levels in the brain regions. BDNF is vital for synaptic plasticity and hence for neuro-protection. Similar results were reported by another study. By mitigating the oxidative stress in the brain, cannabidiol can treat and prevent the symptoms of bipolar disorder.
Bipolar disorder patients often report subjective mood improvement after marijuana use. A small research study that enrolled 43 bipolar disorder patients reported remarkable reduction in total mood disturbance in marijuana smokers, while a slight worsening of symptoms was observed in pure marijuana users. Most of the patients who reported mood improvements were diagnosed with worse mood ratings before marijuana use. This empirical evidence can support the anecdotal claims that cannabis can treat mood-related symptoms.