Thursday, October 29, 2020

Brain Cell Death Is A Possible Trigger Of Multiple Sclerosis Must Read

Must Read

BARACK OBAMA : AMERICA WANTS ME BACK FOR A 3RD TERM

He was supposed to retire to a triumphant post-presidency. Then Trump happened. Now, as Jason Zengerle reports, Obama is...

Pennsylvania GOP Sen. Pat Toomey Won’t Run For Re-Election in 2022

Pennsylvania Republican Sen. Pat Toomey has announced that he will not run for reelection in 2022. “I will not be...

Barack Obama Reportedly Skeptical of Joe Biden’s 2020 White House Run

The presidential election is officially less than 30 days away. With that in mind, we thought it would be helpful...

Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medicine. The death of these cells initiates an autoimmune response against myelin, the main characteristic of the disease, which leads to MS-like symptoms in mice

This reaction can be prevented, however, through the application of specially developed nanoparticles, even after the loss of those brain cells. The nanoparticles are being developed for clinical trials that could lead to new treatments in humans.“Although this was a study in mice, we’ve shown for the first time one possible mechanism that can trigger MS — the death of the cells responsible for generating myelin can lead to the activation of an autoimmune response against myelin,” said study co-senior author Brian Popko, PhD, Jack Miller Professor of Neurological Disorders at the University of Chicago. “Protecting these cells in susceptible individuals might help delay or prevent MS.”

Multiple sclerosis is a neurological disease involving an abnormal immune response against myelin, which leads to the progressive deterioration of a wide range of body functions. MS is thought to affect 2.5 million people worldwide, and has unclear causes and no known cure.To study how MS is triggered, Popko, with collaborator Stephen Miller, PhD, Judy Gugenheim Research Professor of Microbiology-Immunology at Northwestern University Feinberg School of Medicine, and their teams developed a genetically engineered mouse model that allowed them to target oligodendrocytes, the brain cells that produce myelin.

By specifically killing oligodendrocytes, the team observed MS-like symptoms that affected the ability of the mice to walk. After this initial event, the central nervous systems of the mice regenerated their myelin-producing cells, enabling them to walk again. But about six months later, the MS-like symptoms came barreling back.“To our knowledge, this is the first evidence that oligodendrocyte death can trigger myelin autoimmunity, initiating inflammation and tissue damage in the central nervous system during MS,” said study co-author Maria Traka, PhD, research associate professor in neurology at the University of Chicago.possible causes of oligodendrocyte death are developmental abnormalities, viruses, bacterial toxins or environmental pollutants. In humans, the researchers hypothesize MS could develop years after an initial injury to the brain triggers oligodendrocyte death.

LEAVE A REPLY

Please enter your comment!
Please enter your name here

- Advertisement -

Latest News

BARACK OBAMA : AMERICA WANTS ME BACK FOR A 3RD TERM

He was supposed to retire to a triumphant post-presidency. Then Trump happened. Now, as Jason Zengerle reports, Obama is...

Pennsylvania GOP Sen. Pat Toomey Won’t Run For Re-Election in 2022

Pennsylvania Republican Sen. Pat Toomey has announced that he will not run for reelection in 2022. “I will not be running for reelection in 2022...

Barack Obama Reportedly Skeptical of Joe Biden’s 2020 White House Run

The presidential election is officially less than 30 days away. With that in mind, we thought it would be helpful to remind readers that despite...

LeBron James Walks Off Court With Time Left on Clock During NBA Finals

However, those who are watching got to see Los Angeles Lakers superstar LeBron James throw a hissy fit on Monday night after his team...

AOC Says Dems Must Consider Impeaching Trump, Barr To Stop Supreme Court Nomination

Impeachment would force the U.S. Senate to hold a trial at a time when it has precious few days left on its calendar to...
- Advertisement -

More Articles Like This